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Article

Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer

9 Feb 2016

Abstract excerpt

PURPOSE: SMAD4 loss is associated with the development of metastases and poor prognosis. We evaluated expression of SMAD4 protein and its association with tumor characteristics, including biomarkers and outcome in terms of relapse-free survival and overall survival. EXPERIMENTAL DESIGN: We used 1,564 stage II/III colon cancer samples from PETACC-3 to evaluate SMAD4 expression by immunohistochemistry. SMAD4...

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PMID: 26861460
DOI: 10.1158/1078-0432.ccr-15-0939

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