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Article

Bone morphogenetic protein antagonist gremlin-1 regulates colon cancer progression

8 Aug 2014

Abstract excerpt

Bone morphogenetic proteins (BMP) are phylogenetically conserved signaling molecules of the transforming growth factor-beta (TGF-beta) superfamily of proteins, involved in developmental and (patho)physiological processes, including cancer. BMP signaling has been regarded as tumor-suppressive in colorectal cancer (CRC) by reducing cancer cell proliferation and invasion, and by impairing epithelial-to-mesenchymal...

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PMID: 25153376
DOI: 10.1515/hsz-2014-0221

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