Article
The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.
Diabetologia - 1 Jan 2008
Sparsø T, Andersen G, Nielsen T, Burgdorf K S, Gjesing A P, Nielsen A L, Albrechtsen A, Rasmussen S S, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Madsbad S, Hansen T, Pedersen O
Abstract excerpt
AIMS/HYPOTHESIS: Recent genome-wide association studies have suggested that a polymorphism in GCKR, the gene encoding the glucokinase regulatory protein, is involved in triacylglycerol regulation. Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly fasting hypertriacylglycerolaemia) and traits related to pancreatic beta cell function....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.