Article
Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.
Diabetes - 1 Mar 2009
Tam Claudia H T, Ma Ronald C W, So Wing Yee, Wang Ying, Lam Vincent K L, Germer Soren, Martin Mitchell, Chan Juliana C N, Ng Maggie C Y
Abstract excerpt
OBJECTIVE: Recent studies in European populations have reported a reciprocal association of glucokinase regulatory protein (GCKR) gene with triglyceride versus fasting plasma glucose (FPG) levels and type 2 diabetes risk. GCKR is a rate-limiting factor of glucokinase (GCK), which functions as a key glycolytic enzyme for maintaining glucose homeostasis. We examined the associations of two common genetic...
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