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Article

GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?

Cardiovascular diabetology - 29 Nov 2010

Mohás Márton, Kisfali Péter, Járomi Luca, Maász Anita, Fehér Eszter, Csöngei Veronika, Polgár Noémi, Sáfrány Eniko, Cseh Judit, Sümegi Katalin, Hetyésy Katalin, Wittmann István, Melegh Béla

Abstract excerpt

BACKGROUND: Recent studies revealed that glucokinase regulatory protein (GCKR) variants (rs780094 and rs1260326) are associated with serum triglycerides and plasma glucose levels. Here we analyzed primarily the association of these two variants with the lipid profile and plasma glucose levels in...

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Identifiers

PMID: 21114848
DOI: 10.1186/1475-2840-9-79
PMCID: PMC3009616

Genes

GCKR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21114848-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?PMID 21114848Read ↗

GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adultsSemantic proximity Read ↗

GCKR Common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adultsSemantic proximity Read ↗

GCKR Common Functional Polymorphisms are Associated with Metabolic Syndrome and its Components: A 10-Year Retrospective Cohort Study in Iranian AdultsSemantic proximity Read ↗

Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children.Semantic proximity Read ↗

Association of the GCKR rs780094 polymorphism with metabolic traits including carotid intima-media thickness in Japanese community-dwelling men, but not in women.Semantic proximity Read ↗

Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study.Semantic proximity Read ↗

A case-control study and meta-analysis confirm glucokinase regulatory gene rs780094 is a risk factor for gestational diabetes mellitus.Semantic proximity Read ↗

GCKR polymorphism influences liver fat content in patients with type 2 diabetes.Semantic proximity Read ↗

The GCKR Gene Polymorphism rs780094 is a Risk Factor for Gestational Diabetes in a Brazilian Population.Semantic proximity Read ↗

Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.Semantic proximity Read ↗

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.Semantic proximity Read ↗

Association of glucokinase regulatory protein polymorphism with type 2 diabetes and fasting plasma glucose: a meta-analysis.Semantic proximity Read ↗

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