Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.

doi:10.3945/ajcn.2008.26363

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.

The American journal of clinical nutrition - 1 Jan 2009

Perez-Martinez Pablo, Corella Dolores, Shen Jian, Arnett Donna K, Yiannakouris Nikos, Tai E Syong, Orho-Melander Marju, Tucker Katherine L, Tsai Michael, Straka Robert J, Province Michael, Kai Chew Suok, Perez-Jimenez Francisco, Lai Chao-Qiang, Lopez-Miranda Jose, Guillen Marisa, Parnell Laurence D, Borecki Ingrid, Kathiresan Sekar, Ordovas Jose M

Abstract excerpt

BACKGROUND: Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol. OBJECTIVE: We investigated the combined effects of the GCKR rs780094C-->T, APOA5 -1131T-->C, and APOA5 56C-->G single nucleotide polymorphisms (SNPs) on fasting triacylglycerol in several...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein A-V

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins A

Share to Dietary Fats

Share to Fasting

Share to Hypertriglyceridemia

Share to Hypolipidemic Agents

Share to Postprandial Period

Share to Triglycerides

Source

Open in PubMed Open full text

Identifiers

PMID: 19056598
DOI: 10.3945/ajcn.2008.26363
PMCID: PMC2647710

Genes

APOA5
GCKR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.PMID 19056598Read ↗

The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.Semantic proximity Read ↗

Integrating genetics and lifestyles for precision nutrition in hypertriglyceridemia: A UK Biobank and KoGES analysis.Semantic proximity Read ↗

The -1131T-->C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men.Semantic proximity Read ↗

A promoter variant of the APOA5 gene increases atherogenic LDL levels and arterial stiffness in hypertriglyceridemic patients.Semantic proximity Read ↗

Genetic variants associated with triglyceride metabolism and fasting triglyceride concentrations: a systematic review and a meta-analysis.Semantic proximity Read ↗

Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.Semantic proximity Read ↗

Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study.Semantic proximity Read ↗

Discrete associations of the GCKR variant with metabolic risk in a Chinese population: longitudinal change analysis.Semantic proximity Read ↗

Common functional variants of APOA5 and GCKR accumulate gradually in association with triglyceride increase in metabolic syndrome patients.Semantic proximity Read ↗

Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism.Semantic proximity Read ↗

Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study.Semantic proximity Read ↗

The Genetic Basis of Hypertriglyceridemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.