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Article

Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children.

Diabetes & metabolism - 1 Nov 2011

Horvatovich K, Bokor S, Polgar N, Kisfali P, Hadarits F, Jaromi L, Csongei V, Repasy J, Molnar D, Melegh B

Abstract excerpt

OBJECTIVE: Recently, the association of the natural variants rs1260326 and rs780094 of the glucokinase regulatory protein (GCKR) gene with increased fasting triglycerides and decreased fasting plasma glucose in diabetic adults was reported; the minor alleles were also found to reduce the risk of type 2 diabetes. The present study examined the possible associations of these variants with triglycerides and glucose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adaptor Proteins, Signal Transducing
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Source

Identifiers

PMID: 21511510
DOI: 10.1016/j.diabet.2011.02.003

Genes

GCKR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children.PMID 21511510Read ↗

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GCKR Common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adultsSemantic proximity Read ↗

GCKR Common Functional Polymorphisms are Associated with Metabolic Syndrome and its Components: A 10-Year Retrospective Cohort Study in Iranian AdultsSemantic proximity Read ↗

Glucokinase regulatory protein (GCKR) gene rs4425043 polymorphism is associated with overweight and obesity in Chinese women.Semantic proximity Read ↗

The GCKR Gene Polymorphism rs780094 is a Risk Factor for Gestational Diabetes in a Brazilian Population.Semantic proximity Read ↗

The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.Semantic proximity Read ↗

Common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: a meta-analysis.Semantic proximity Read ↗

GCKR polymorphism influences liver fat content in patients with type 2 diabetes.Semantic proximity Read ↗

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