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Article

The Rac1 polybasic region is required for interaction with its effector PRK1.

The Journal of biological chemistry - 18 Jan 2008

Modha Rakhee, Campbell Louise J, Nietlispach Daniel, Buhecha Heeran R, Owen Darerca, Mott Helen R

Abstract excerpt

Protein kinase C-related kinase 1 (PRK1 or PKN) is involved in regulation of the intermediate filaments of the actin cytoskeleton, as well as having effects on processes as diverse as mitotic timing and apoptosis. It is activated by interacting with the Rho family small G proteins and arachidonic acid or by caspase cleavage. We have previously shown that the HR1b of PRK1 binds exclusively to Rac1, whereas the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18006505
DOI: 10.1074/jbc.M706760200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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