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Article

The last five amino acid residues at the C-terminus of PRK1/PKN is essential for full lipid responsiveness.

Cellular signalling - 1 Sept 2005

Lim Wee Guan, Zhu Yimin, Wang Chern-Hoe, Tan Bee Jen, Armstrong Jeffrey S, Dokland Terje, Yang Hongyuan, Zhu Yi-Zhun, Teo Tian Seng, Duan Wei

Abstract excerpt

PRK1/PKN is a member of the protein kinase C (PKC) superfamily of serine/threonine protein kinases. Despite its important role as a RhoA effector, limited information is available regarding how this kinase is regulated. We show here that the last seven amino acid residues at the C-terminus is dispensable for the catalytic activity of PRK1 but is critical for the in vivo stability of this kinase. Surprisingly, the...

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Identifiers

PMID: 15993750
DOI: 10.1016/j.cellsig.2004.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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