Article
Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1).
The Journal of biological chemistry - 12 Dec 2003
Owen Darerca, Lowe Peter N, Nietlispach Daniel, Brosnan C Elaine, Chirgadze Dimitri Y, Parker Peter J, Blundell Tom L, Mott Helen R
Abstract excerpt
PRK1 is a serine/threonine kinase that belongs to the protein kinase C superfamily. It can be activated either by members of the Rho family of small G proteins, by proteolysis, or by interaction with lipids. Here we investigate the binding of PRK1 to RhoA and Rac1, two members of the Rho family. We demonstrate that PRK1 binds with a similar affinity to RhoA and Rac1. We present the solution structure of the...
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