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Article

The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling.

Cellular signalling - 1 Sept 2006

Lim Wee Guan, Tan Bee Jen, Zhu Yimin, Zhou Shufeng, Armstrong Jeffrey S, Li Qiu Tian, Dong Qihan, Chan Eli, Smith Derek, Verma Chandra, Tan Seng-Lai, Duan Wei

Abstract excerpt

PRK1 is a lipid- and Rho GTPase-activated serine/threonine protein kinase implicated in the regulation of receptor trafficking, cytoskeletal dynamics and tumorigenesis. Although Rho binding has been mapped to the HR1 region in the regulatory domain of PRK1, the mechanism involved in the control of PRK1 activation following Rho binding is poorly understood. We now provide the first evidence that the very...

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Identifiers

PMID: 16427251
DOI: 10.1016/j.cellsig.2005.11.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling.PMID 16427251Read ↗

The last five amino acid residues at the C-terminus of PRK1/PKN is essential for full lipid responsiveness.Semantic proximity Read ↗

The Rac1 polybasic region is required for interaction with its effector PRK1.Semantic proximity Read ↗

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Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1).Semantic proximity Read ↗

Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.Semantic proximity Read ↗

Characterization of the interaction between RhoA and the amino-terminal region of PKN.Semantic proximity Read ↗

PRK1 is targeted to endosomes by the small GTPase, RhoB.Semantic proximity Read ↗

The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity.Semantic proximity Read ↗

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1.Semantic proximity Read ↗

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PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation.Semantic proximity Read ↗

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