Article
Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.
Biochemistry - 12 Apr 2011
Hutchinson Catherine L, Lowe Peter N, McLaughlin Stephen H, Mott Helen R, Owen Darerca
Abstract excerpt
Protein kinase C-related kinases (PRKs) are serine/threonine kinases that are members of the protein kinase C superfamily and can be activated by binding to members of the Rho family of small G proteins via a Rho binding motif known as an HR1 domain. The PRKs contain three tandem HR1 domains at their N-termini. The structure of the HR1a domain from PRK1 in complex with RhoA [Maesaki, R., et al. (1999) Mol. Cell...
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