Article
Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes.
Developmental neurobiology - 1 Feb 2008
Chen Xuqi, Watkins Rebecca, Delot Emmanuele, Reliene Ramune, Schiestl Robert H, Burgoyne Paul S, Arnold Arthur P
Abstract excerpt
To shed light on the biological origins of sex differences in neural tube defects (NTDs), we examined Trp53-null C57BL/6 mouse embryos and neonates at 10.5 and 18.5 days post coitus (dpc) and at birth. We confirmed that female embryos show more NTDs than males. We also examined mice in which the testis-determining gene Sry is deleted from the Y chromosome but inserted onto an autosome as a transgene, producing XX...
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