Article
A single genetic determinant that prevents sex reversal in C57BL-YPOS congenic mice.
Biochemical genetics - 1 Jun 2000
Whitney J B, Mills T M, Lewis R W, Wartell R, Abney T O
Abstract excerpt
Sex determination in the mammalian embryo begins with the activation of a gene on the Y chromosome which triggers a cascade of events that lead to male development. The mechanism by which this gene, designated SRY in humans and Sry in mice (sex determining region of the Y chromosome), is activated remains unknown. Likewise, the downstream target genes for Sry remain unidentified at present. C57BL mice carrying a...
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