Article
Study of the gonocyte cell cycle in irradiated TP53 knockout mouse foetuses and newborns.
International journal of radiation biology - 1 Aug 2002
Moreno S G, Dutrillaux B, Coffigny H
Abstract excerpt
PURPOSE: To investigate the role of p53 in gonocyte cell-cycle arrest in rodents with or without radiation exposure. MATERIALS AND METHODS: Pregnant p53 (+/-) mice, mated with p53 (-/-) males, were exposed to (137)Cs gamma-rays at day 18 postcoitum (p.c.) at doses ranging from 1.5 Gy to 3 Gy. The gonocyte cell cycle was studied in p53 (-/-) male foetuses and newborns after BrdU incorporation and DAPI staining,...
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