Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins.

doi:10.1016/0304-3940(94)90219-4

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Article

Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins.

Neuroscience letters - 21 Nov 1994

Davies A M, Rosenthal A

Abstract excerpt

Cell death plays an important role in regulating cell numbers in a wide variety of tissues during development and throughout life. Cell death can be triggered by changes in the levels of hormones and growth factors and is regulated by the expression of the tumour suppressor gene p53 in many cells...

Topics

Animals
Cell Death
Embryo, Mammalian
Genes, p53
Mice
Mice, Knockout
Mutation
Nerve Growth Factors
Neurons
Reference Values

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