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Article

The effect of Trp53 gene-dosage and parent-of-origin of inheritance on mouse gamete and embryo function in vitro.

Biology of reproduction - 1 Jun 2012

Li A, Ganeshan L, O'Neill C

Abstract excerpt

The transformation-related protein 53 (TRP53) has a canonical role as the "guardian of the genome," serving to protect against the propagation of cells with genomic damage. Autocrine trophic signals act to block the accumulation of TRP53 in the normal preimplantation embryo. Culture of the early embryo at limiting dilutions in simple defined media limits autocrine signaling, resulting in the accumulation of...

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PMID: 22441798
DOI: 10.1095/biolreprod.111.097741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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