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Article

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.

Nature - 6 Dec 2007

Nejentsev Sergey, Howson Joanna M M, Walker Neil M, Szeszko Jeffrey, Field Sarah F, Stevens Helen E, Reynolds Pamela, Hardy Matthew, King Erna, Masters Jennifer, Hulme John, Maier Lisa M, Smyth Deborah, Bailey Rebecca, Cooper Jason D, Ribas Gloria, Campbell R Duncan, Clayton David G, Todd John A

Abstract excerpt

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1-3), but these genes cannot completely explain the association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18004301
DOI: 10.1038/nature06406
PMCID: PMC2703779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.PMID 18004301Read ↗

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