Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC.

doi:10.2337/dc19-0986

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Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC.

Diabetes care - 1 Feb 2020

Mishra Rajashree, Åkerlund Mikael, Cousminer Diana L, Ahlqvist Emma, Bradfield Jonathan P, Chesi Alessandra, Hodge Kenyaita M, Guy Vanessa C, Brillon David J, Pratley Richard E, Rickels Michael R, Vella Adrian, Ovalle Fernando, Harris Ronald I, Melander Olle, Varvel Stephen, Hakonarson Hakon, Froguel Phillippe, Lonsdale John T, Mauricio Didac, Schloot Nanette C, Khunti Kamlesh, Greenbaum Carla J, Yderstræde Knud B, Tuomi Tiinamaija, Voight Benjamin F, Schwartz Stanley, Boehm Bernhard O, Groop Leif, Leslie Richard David, Grant Struan F A

Abstract excerpt

OBJECTIVE: The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, the strength of association is likely attenuated compared with that for childhood-onset type 1 diabetes. In this study, we recapitulate independent effects in the MHC class I region in a population with type 1 diabetes and then determine whether such conditioning in LADA yields potential genetic...

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Identifiers

PMID: 31843946
DOI: 10.2337/dc19-0986
PMCID: PMC6971787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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