Article
Multiple HLA epitopes contribute to type 1 diabetes susceptibility.
Diabetes - 1 Jan 2014
Roark Christina L, Anderson Kirsten M, Simon Lucas J, Schuyler Ronald P, Aubrey Michael T, Freed Brian M
Abstract excerpt
Disease susceptibility for type 1 diabetes is strongly associated with the inheritance of specific HLA alleles. However, conventional allele frequency analysis can miss HLA associations because many alleles are rare. In addition, disparate alleles that have similar peptide-binding sites, or shared epitopes, can be missed. To identify the HLA shared epitopes associated with diabetes, we analyzed high-resolution...
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