Extreme genetic risk for type 1A diabetes in the post-genome era.

doi:10.1016/j.jaut.2008.03.003

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Article

Extreme genetic risk for type 1A diabetes in the post-genome era.

Journal of autoimmunity - 1 Aug 2008

Baschal Erin E, Eisenbarth George S

Abstract excerpt

A series of genes and loci influencing the genetic risk of type 1A (immune-mediated) diabetes are now well characterized. These include genes of the major histocompatibility complex (MHC), polymorphisms 5' of the insulin gene, and PTPN22, as well as more recently defined loci from genome-wide association studies. By far the major determinants of risk for type 1A diabetes are genes within or linked to the MHC and...

Topics

Algorithms
Diabetes Mellitus, Type 1
Genetic Predisposition to Disease
Genome, Human
Humans
Insulin
Major Histocompatibility Complex
Minisatellite Repeats
Polymorphism, Genetic
Protein Tyrosine Phosphatase, Non-Receptor Type 22

Source

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Identifiers

PMID: 18450419
DOI: 10.1016/j.jaut.2008.03.003
PMCID: PMC2465466

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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