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Article

Genomic variation at the MDR1 promoter and P-glycoprotein expression and activity in AML patients.

Leukemia research - 1 Jun 2008

Lourenço J J, Maia R C, Scheiner M A M, Vasconcelos F C, Moreira M A M

Abstract excerpt

Sequence variation at the proximal MDR1 promoter of 72 patients with acute myeloid leukemia (AML) was investigated and its association with P-glycoprotein (Pgp) expression and activity using flow cytometry were analyzed. Two variants were found: -129T/C and a non-described A/T substitution at position +68 of intron 1 in one patient. Three different genotypes were identified for single nucleotide polymorphism...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genome, Human

Share to Leukemia, Myeloid, Acute

Share to Promoter Regions, Genetic

Share to Reverse Transcriptase Polymerase Chain Reaction

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Source

Identifiers

PMID: 18001833
DOI: 10.1016/j.leukres.2007.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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