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Article

Multidrug-related protein 1 (MRP1) polymorphisms rs129081, rs212090, and rs212091 predict survival in normal karyotype acute myeloid leukemia.

Annals of hematology - 1 Sept 2020

Kunadt Desiree, Dransfeld Christian, Dill Claudia, Schmiedgen Maria, Kramer Michael, Altmann Heidi, Röllig Christoph, Bornhäuser Martin, Mahlknecht Ulrich, Schaich Markus, Stölzel Friedrich

Abstract excerpt

Resistant disease is still a main obstacle in acute myeloid leukemia (AML) treatment. Therefore, individual genetic variations affecting therapy response are gaining increasing importance. Both SNPs and ABC transporter genes could already be associated with drug resistance. Here, we report allelic variants of MRP1 (ABCC1) SNPs rs129081, rs212090, and rs212091 with significant influences on survival in AML...

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Share to Adolescent
Share to Leukemia, Myeloid, Acute
Share to Multidrug Resistance-Associated Proteins
Share to Polymorphism, Single Nucleotide
Share to Predictive Value of Tests
Share to Survival Rate
Share to Young Adult

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Identifiers

PMID: 32621177
DOI: 10.1007/s00277-020-04163-7
PMCID: PMC7419446

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