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Article

Influence of functional MDR1 gene polymorphisms on P-glycoprotein activity in CD34+ hematopoietic stem cells.

Haematologica - 1 Jun 2002

Calado Rodrigo T, Falcão Roberto P, Garcia Aglair B, Gabellini Sérgio M, Zago Marco A, Franco Rendrik F

Abstract excerpt

BACKGROUND AND OBJECTIVES: Expression of the multidrug resistance P-glycoprotein, a transmembrane drug transporter, is influenced by recently described polymorphisms of the human MDR1 gene. Hematopoietic cells, such as lymphocytes, and hematopoietic stem cells, express P-glycoprotein, but the effect of MDR1 gene polymorphisms on P-glycoprotein activity in stem cells is unknown. We investigated whether T-129C,...

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Topics

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Share to Antigens, CD34
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, MDR

Share to Hematopoietic Stem Cells

Share to Polymorphism, Single Nucleotide

Share to Rhodamine 123

Source

Identifiers

PMID: 12031911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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