Article
Sequence comparison of putative regulatory DNA of the 5' flanking region of the myeloperoxidase gene in normal and leukemic bone marrow cells.
Leukemia - 1 Sept 1993
Austin G E, Lam L, Zaki S R, Chan W C, Hodge T, Hou J, Swan D, Zhang W, Racine M, Whitsett C
Abstract excerpt
Myeloperoxidase (MPO) is an enzyme which is exclusively expressed in immature myeloid cells with downregulation of gene expression occurring during granulocytic maturation. Levels of MPO RNA, protein, and enzyme activity differ, usually in a concordant fashion, among the various classes of acute...
Topics
- Base Sequence
- Bone Marrow
- Bone Marrow Cells
- DNA, Neoplasm
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Leukemic
- Humans
- Leukemia, Myeloid, Acute
- Molecular Sequence Data
- Mutation
- Peroxidase