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Article

MDR1 gene-related clonal selection and P-glycoprotein function and expression in relapsed or refractory acute myeloid leukemia.

Blood - 1 Jun 2001

van den Heuvel-Eibrink M M, Wiemer E A, de Boevere M J, van der Holt B, Vossebeld P J, Pieters R, Sonneveld P

Abstract excerpt

The expression of P-glycoprotein (P-gp), encoded by the MDR1 gene, is an independent adverse prognostic factor for response and survival in de novo acute myeloid leukemia (AML). Little is known about MDR1 expression during the development of disease. The present study investigated whether MDR1 gene- related clonal selection occurs in the development from diagnosis to relapsed AML, using a genetic polymorphism of...

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Identifiers

PMID: 11369657
DOI: 10.1182/blood.v97.11.3605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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