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Article

MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients.

Cancer research - 1 Sept 2002

Illmer Thomas, Schuler Ulrich S, Thiede Christian, Schwarz Ute I, Kim Richard B, Gotthard Sebastian, Freund Daniel, Schäkel Ulrike, Ehninger Gerhard, Schaich Markus

Abstract excerpt

Allelic variants of the MDR-1 gene have been shown recently to influence protein expression and P-glycoprotein (P-gp) function in healthy volunteers. Therefore, 405 acute myeloid leukemia patients were investigated for somatic genotypes of the three most frequent single nucleotide polymorphisms (SNPs) in exons 12, 21, and 26. In all three loci, homozygous wild-type alleles were classified as genotype A,...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to Genes, MDR

Share to Leukemia, Myeloid

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Share to Polymorphism, Single-Stranded Conformational

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PMID: 12208746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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