Article
Development of an allele-specific minimal residual disease assay for patients with juvenile myelomonocytic leukemia.
Blood - 1 Feb 2008
Archambeault Sophie, Flores Nikki J, Yoshimi Ayami, Kratz Christian P, Reising Miriam, Fischer Alexandra, Noellke Peter, Locatelli Franco, Sedlacek Petr, Flotho Christian, Zecca Marco, Emanuel Peter D, Castleberry Robert P, Niemeyer Charlotte M, Bader Peter, Loh Mignon L
Abstract excerpt
Juvenile myelomonocytic leukemia is an aggressive and frequently lethal myeloproliferative disorder of childhood. Somatic mutations in NRAS, KRAS, or PTPN11 occur in 60% of cases. Monitoring disease status is difficult because of the lack of characteristic leukemic blasts at diagnosis. We designed a fluorescently based, allele-specific polymerase chain reaction assay called TaqMAMA to detect the most common RAS...
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