Application of allele-specific quantitative PCR using genomic DNA to monitor minimal residual disease based on mutant gene levels following allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies: comparison of mutant levels with autologous DNA percentage by short tandem repeat-PCR.

doi:10.1016/j.cca.2011.11.017

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Article

Application of allele-specific quantitative PCR using genomic DNA to monitor minimal residual disease based on mutant gene levels following allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies: comparison of mutant levels with autologous DNA percentage by short tandem repeat-PCR.

Clinica chimica acta; international journal of clinical chemistry - 18 Feb 2012

Taira Chiaki, Matsuda Kazuyuki, Saito Shoji, Sakashita Kazuo, Sugano Mitsutoshi, Okumura Nobuo, Honda Takayuki

Abstract excerpt

BACKGROUND: Quantitative evaluation of minimal residual disease (MRD) following hematopoietic stem cell transplantation (HSCT) is indispensable for patients with hematological malignancies. In addition to established MRD markers such as immunoglobulin and T-cell receptor gene rearrangements, fusion genes, or aberrantly expressed genes, single nucleotide mutations are considered one of the MRD markers that reflect...

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PMID: 22138486
DOI: 10.1016/j.cca.2011.11.017

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PTPN11

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