Article
Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia.
British journal of haematology - 1 Feb 2010
Matsuda Kazuyuki, Sakashita Kazuo, Taira Chiaki, Tanaka-Yanagisawa Miyuki, Yanagisawa Ryu, Shiohara Masaaki, Kanegane Hirokazu, Hasegawa Daiichiro, Kawasaki Keiichiro, Endo Mikiya, Yajima Shuhei, Sasaki Shinya, Kato Keisuke, Koike Kazutoshi, Kikuchi Akira, Ogawa Atsushi, Watanabe Akihiro, Sotomatsu Manabu, Nonoyama Shigeaki, Koike Kenichi
Abstract excerpt
To evaluate minimal residual disease (MRD) after chemotherapy and haematopoietic stem cell transplantation in juvenile myelomonocytic leukaemia (JMML), a locked nucleic acid-allele specific quantitative polymerase chain reaction (LNA-AS-qPCR) was developed for 13 patients (four types of PTPN11 mutation and four types of RAS mutation). The post-transplant MRD detected by LNA-AS-qPCR analysis was well correlated...
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