Article
Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia.
PloS one - 1 Jan 2015
Sakaguchi Hirotoshi, Muramatsu Hideki, Okuno Yusuke, Makishima Hideki, Xu Yinyan, Furukawa-Hibi Yoko, Wang Xinan, Narita Atsushi, Yoshida Kenichi, Shiraishi Yuichi, Doisaki Sayoko, Yoshida Nao, Hama Asahito, Takahashi Yoshiyuki, Yamada Kiyofumi, Miyano Satoru, Ogawa Seishi, Maciejewski Jaroslaw P, Kojima Seiji
Abstract excerpt
Juvenile myelomonocytic leukemia (JMML), an overlap of myelodysplastic / myeloproliferative neoplasm, is an intractable pediatric myeloid neoplasm. Epigenetic regulation of transcription, particularly by CpG methylation, plays an important role in tumor progression, mainly by repressing tumor-suppressor genes. To clarify the clinical importance of aberrant DNA methylation, we studied the hypermethylation status...
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