Article
RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.
Nature communications - 19 Dec 2017
Lipka Daniel B, Witte Tania, Toth Reka, Yang Jing, Wiesenfarth Manuel, Nöllke Peter, Fischer Alexandra, Brocks David, Gu Zuguang, Park Jeongbin, Strahm Brigitte, Wlodarski Marcin, Yoshimi Ayami, Claus Rainer, Lübbert Michael, Busch Hauke, Boerries Melanie, Hartmann Mark, Schönung Maximilian, Kilik Umut, Langstein Jens, Wierzbinska Justyna A, Pabst Caroline, Garg Swati, Catalá Albert, De Moerloose Barbara, Dworzak Michael, Hasle Henrik, Locatelli Franco, Masetti Riccardo, Schmugge Markus, Smith Owen, Stary Jan, Ussowicz Marek, van den Heuvel-Eibrink Marry M, Assenov Yassen, Schlesner Matthias, Niemeyer Charlotte, Flotho Christian, Plass Christoph
Abstract excerpt
Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative disorder of early childhood characterized by mutations activating RAS signaling. Established clinical and genetic markers fail to fully recapitulate the clinical and biological heterogeneity of this disease. Here we report DNA methylome analysis and mutation profiling of 167 JMML samples. We identify three JMML subgroups with unique...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.