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Juvenile myelomonocytic leukemia: who’s the driver at the wheel?

23 Jan 2019

Abstract excerpt

Abstract Juvenile myelomonocytic leukemia (JMML) is a unique clonal hematopoietic disorder of early childhood. It is classified as an overlap myeloproliferative/myelodysplastic neoplasm by the World Health Organization and shares some features with chronic myelomonocytic leukemia in adults. JMML pathobiology is characterized by constitutive activation of the Ras signal transduction pathway. About 90% of patients...

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PMID: 30670449
DOI: 10.1182/blood-2018-11-844688

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