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Article

Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia.

Blood - 16 Aug 2012

Doisaki Sayoko, Muramatsu Hideki, Shimada Akira, Takahashi Yoshiyuki, Mori-Ezaki Makiko, Sato Masanori, Kawaguchi Hiroyuki, Kinoshita Akitoshi, Sotomatsu Manabu, Hayashi Yasuhide, Furukawa-Hibi Yoko, Yamada Kiyofumi, Hoshino Hideaki, Kiyoi Hitoshi, Yoshida Nao, Sakaguchi Hirotoshi, Narita Atsushi, Wang Xinan, Ismael Olfat, Xu Yinyan, Nishio Nobuhiro, Tanaka Makito, Hama Asahito, Koike Kenichi, Kojima Seiji

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is a rare pediatric myeloid neoplasm characterized by excessive proliferation of myelomonocytic cells. Somatic mutations in genes involved in GM-CSF signal transduction, such as NRAS, KRAS, PTPN11, NF1, and CBL, have been identified in more than 70% of children with JMML. In the present study, we report 2 patients with somatic mosaicism for oncogenic NRAS mutations (G12D...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myelomonocytic, Juvenile

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Source

Identifiers

PMID: 22753870
DOI: 10.1182/blood-2012-02-406090

Genes

NRAS
CBL
KRAS
PTPN11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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