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Article

Proteomic Analysis of an Induced Pluripotent Stem Cell Model Reveals Strategies to Treat Juvenile Myelomonocytic Leukemia.

Journal of proteome research - 3 Jan 2020

Pearson Stella, Guo Baoqiang, Pierce Andrew, Azadbakht Narges, Brazzatti Julie A, Patassini Stefano, Mulero-Navarro Sonia, Meyer Stefan, Flotho Christian, Gelb Bruce D, Whetton Anthony D

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm of early childhood with a poor survival rate, thus there is a requirement for improved treatment strategies. Induced pluripotent stem cells offer the ability to model disease and develop new treatment strategies. JMML is frequently associated with mutations in PTPN11. Children with Noonan syndrome, a development disorder, have an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31657576
DOI: 10.1021/acs.jproteome.9b00495
PMCID: PMC6942217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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