Article
RASA4 undergoes DNA hypermethylation in resistant juvenile myelomonocytic leukemia.
Epigenetics - 1 Sept 2014
Poetsch Anna R, Lipka Daniel B, Witte Tania, Claus Rainer, Nöllke Peter, Zucknick Manuela, Olk-Batz Christiane, Fluhr Silvia, Dworzak Michael, De Moerloose Barbara, Starý Jan, Zecca Marco, Hasle Henrik, Schmugge Markus, van den Heuvel-Eibrink Marry M, Locatelli Franco, Niemeyer Charlotte M, Flotho Christian, Plass Christoph
Abstract excerpt
Aberrant DNA methylation at specific genetic loci is a key molecular feature of juvenile myelomonocytic leukemia (JMML) with poor prognosis. Using quantitative high-resolution mass spectrometry, we identified RASA4 isoform 2, which maps to chromosome 7 and encodes a member of the GAP1 family of GTPase-activating proteins for small G proteins, as a recurrent target of isoform-specific DNA hypermethylation in JMML...
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