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Article

Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype.

BMC cancer - 13 Nov 2007

Lentini Laura, Amato Angela, Schillaci Tiziana, Di Leonardo Aldo

Abstract excerpt

BACKGROUND: Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN). CIN is characterized by chromosomal aberrations, gains or losses of whole chromosomes (aneuploidy), and it is often associated with centrosome amplification. Centrosomes control cell division by forming a bipolar mitotic spindle and play an...

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Identifiers

PMID: 17999753
DOI: 10.1186/1471-2407-7-212
PMCID: PMC2206046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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