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Article

Amplification/Overexpression of a Mitotic Kinase Gene in Human Bladder Cancer

3 Sept 2002

Abstract excerpt

BACKGROUND: The mitotic kinase-encoding gene STK15/BTAK/ AuroraA is associated with aneuploidy and transformation when overexpressed in mammalian cells. STK15 overexpression activates an unknown oncogenic pathway that involves centrosome amplification and results in missegregation of chromosomes. Because clinical prognosis and tumor aneuploidy are tightly linked in human bladder cancer, we examined whether...

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PMID: 12208897
DOI: 10.1093/jnci/94.17.1320

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Amplification/Overexpression of a Mitotic Kinase Gene in Human Bladder CancerPMID 12208897Read ↗

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