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Article

Chromosomal instability and APC gene mutations in human sporadic colorectal adenomas.

The Journal of pathology - 1 Oct 2004

Giaretti Walter, Venesio Tiziana, Prevosto Claudia, Lombardo Federica, Ceccarelli Jenny, Molinu Silvia, Risio Mauro

Abstract excerpt

The mechanisms by which adenomatous polyposis coli (APC) gene mutations contribute to colorectal tumourigenesis and progression are still not fully understood. Using in vitro mouse embryonic stem cells, APC mutations have been proposed to dysregulate the interactions between kinetochores and microtubules during mitosis, leading to chromosomal instability (CIN) and aneuploidy. A link between APC mutations and...

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Source

Identifiers

PMID: 15376262
DOI: 10.1002/path.1623

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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