Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types.

doi:10.1093/carcin/bgi085

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Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types.

Carcinogenesis - 1 Aug 2005

Ewart-Toland Amanda, Dai Qi, Gao Yu-Tang, Nagase Hiroki, Dunlop Malcolm G, Farrington Susan M, Barnetson Rebecca A, Anton-Culver Hoda, Peel David, Ziogas Argyrios, Lin Dongxin, Miao Xiaoping, Sun Tong, Ostrander Elaine A, Stanford Janet L, Langlois Mariela, Chan June M, Yuan Jinwei, Harris Curtis C, Bowman Elise D, Clayman Gary L, Lippman Scott M, Lee J Jack, Zheng Wei, Balmain Allan

Abstract excerpt

STK15 (Aurora-A) is a serine/threonine kinase involved in mitotic chromosomal segregation. A genetic variant in STK15 T+91A (resulting in the amino acid substitution F31I) is associated with increased aneuploidy in colon tumors and cell transformation in vitro. Since this polymorphism plays a role in mitotic control-a process critical for all cancer types-we conducted association analyses for risk of cancer...

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PMID: 15802297
DOI: 10.1093/carcin/bgi085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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