Article
Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis.
The Journal of cell biology - 2 Jul 2018
Lopes Carla A M, Mesquita Marta, Cunha Ana Isabel, Cardoso Joana, Carapeta Sara, Laranjeira Cátia, Pinto António E, Pereira-Leal José B, Dias-Pereira António, Bettencourt-Dias Mónica, Chaves Paula
Abstract excerpt
Centrosome abnormalities are a typical hallmark of human cancers. However, the origin and dynamics of such abnormalities in human cancer are not known. In this study, we examined centrosomes in Barrett's esophagus tumorigenesis, a well-characterized multistep pathway of progression, from the premalignant condition to the metastatic disease. This human cancer model allows the study of sequential steps of...
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