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Article

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human.

Nature genetics - 1 Aug 2003

Ewart-Toland Amanda, Briassouli Paraskevi, de Koning John P, Mao Jian-Hua, Yuan Jinwei, Chan Florence, MacCarthy-Morrogh Lucy, Ponder Bruce A J, Nagase Hiroki, Burn John, Ball Sarah, Almeida Maria, Linardopoulos Spiros, Balmain Allan

Abstract excerpt

Linkage analysis and haplotype mapping in interspecific mouse crosses (Mus musculus x Mus spretus) identified the gene encoding Aurora2 (Stk6 in mouse and STK15 in human) as a candidate skin tumor susceptibility gene. The Stk6 allele inherited from the susceptible M. musculus parent was overexpressed in normal cells and preferentially amplified in tumor cells from F(1) hybrid mice. We identified a common genetic...

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PMID: 12881723
DOI: 10.1038/ng1220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human.PMID 12881723Read ↗

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