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Article

Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.

American journal of human genetics - 1 Dec 2007

Zhernakova Alexandra, Alizadeh Behrooz Z, Bevova Marianna, van Leeuwen Miek A, Coenen Marieke J H, Franke Barbara, Franke Lude, Posthumus Marcel D, van Heel David A, van der Steege Gerrit, Radstake Timothy R D J, Barrera Pilar, Roep Bart O, Koeleman Bobby P C, Wijmenga Cisca

Abstract excerpt

Recently, association of celiac disease with common single-nucleotide polymorphism (SNP) variants in an extensive linkage-disequilibrium block of 480 kb containing the KIAA1109, Tenr, IL2, and IL21 genes has been demonstrated in three independent populations (rs6822844P combined=1.3 x 10(-14)). The KIAA1109/Tenr/IL2/IL21 block corresponds to the Idd3 locus in the nonobese diabetic mouse model of type 1 diabetes...

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Identifiers

PMID: 17999365
DOI: 10.1086/522037
PMCID: PMC2276343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.PMID 17999365Read ↗

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.Semantic proximity Read ↗

Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance.Semantic proximity Read ↗

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Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.Semantic proximity Read ↗

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