Article
Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study.
Arthritis research & therapy - 1 Jan 2009
Teixeira Vitor Hugo, Pierlot Celine, Migliorini Paola, Balsa Alejandro, Westhovens René, Barrera Pilar, Alves Helena, Vaz Carlos, Fernandes Manuela, Pascual-Salcedo Dora, Bombardieri Stefano, Dequeker Jan, Radstake Timothy R, Van Riel Piet, van de Putte Leo, Lopes-Vaz Antonio, Bardin Thomas, Prum Bernard, Cornélis François, Petit-Teixeira Elisabeth
Abstract excerpt
INTRODUCTION: A candidate gene approach, in a large case-control association study in the Dutch population, has shown that a 480 kb block on chromosome 4q27 encompassing KIAA1109/Tenr/IL2/IL21 genes is associated with rheumatoid arthritis. Compared with case-control association studies, family-based studies have the added advantage of controlling potential differences in population structure. Therefore, our aim...
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