Article
Genome-wide association studies in type 1 diabetes, inflammatory bowel disease and other immune-mediated disorders.
Seminars in immunology - 1 Dec 2009
Hakonarson Hakon, Grant Struan F A
Abstract excerpt
Genome-wide association studies have delivered on the promise of uncovering genetic determinants of complex disease. In this review, we provide a summary of recent advances in the identification of multiple variants associated with autoimmune-mediated disorders; specifically type 1 diabetes and inflammatory bowel disease. Sixteen loci, all replicated in independent samples, have now been uncovered for type 1...
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