Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.

Nature - 2 Aug 2007

Hakonarson Hakon, Grant Struan F A, Bradfield Jonathan P, Marchand Luc, Kim Cecilia E, Glessner Joseph T, Grabs Rosemarie, Casalunovo Tracy, Taback Shayne P, Frackelton Edward C, Lawson Margaret L, Robinson Luke J, Skraban Robert, Lu Yang, Chiavacci Rosetta M, Stanley Charles A, Kirsch Susan E, Rappaport Eric F, Orange Jordan S, Monos Dimitri S, Devoto Marcella, Qu Hui-Qi, Polychronakos Constantin

Abstract excerpt

Type 1 diabetes (T1D) in children results from autoimmune destruction of pancreatic beta cells, leading to insufficient production of insulin. A number of genetic determinants of T1D have already been established through candidate gene studies, primarily within the major histocompatibility comple...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Markers

Share to Genome, Human

Share to Lectins, C-Type

Share to Linkage Disequilibrium

Share to Monosaccharide Transport Proteins

Share to Nuclear Family

Source

Identifiers

PMID: 17632545
DOI: 10.1038/nature06010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17632545-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.PMID 17632545Read ↗

Intron polymorphism in the KIAA0350 gene is reproducibly associated with susceptibility to type 1 diabetes (T1D) in the Han Chinese population.Semantic proximity Read ↗

Genome-wide association studies in type 1 diabetes.Semantic proximity Read ↗

Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association StudySemantic proximity Read ↗

Genes Involved in Type 1 Diabetes: An UpdateSemantic proximity Read ↗

A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.Semantic proximity Read ↗

A genome-wide association study identifies novel risk loci for type 2 diabetes.Semantic proximity Read ↗

Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.Semantic proximity Read ↗

Genetic association and machine learning improves discovery and prediction of type 1 diabetesSemantic proximity Read ↗

The past, present, and future of genetic associations in type 1 diabetes.Semantic proximity Read ↗

Association between alleles, haplotypes, and amino acid variations in HLA class II genes and type 1 diabetes in Kuwaiti children.Semantic proximity Read ↗

Type 1 Diabetes Mellitus-Associated Genetic Variants Contribute to Overlapping Immune Regulatory NetworksSemantic proximity Read ↗

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.