Article
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Nature genetics - 1 Jun 2009
Barrett Jeffrey C, Clayton David G, Concannon Patrick, Akolkar Beena, Cooper Jason D, Erlich Henry A, Julier Cécile, Morahan Grant, Nerup Jørn, Nierras Concepcion, Plagnol Vincent, Pociot Flemming, Schuilenburg Helen, Smyth Deborah J, Stevens Helen, Todd John A, Walker Neil M, Rich Stephen S
Abstract excerpt
Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with...
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