Article
Studies on the actin-binding protein HS1 in platelets.
BMC cell biology - 9 Nov 2007
Thomas Steven G, Calaminus Simon D J, Auger Jocelyn M, Watson Stephen P, Machesky Laura M
Abstract excerpt
BACKGROUND: The platelet cytoskeleton mediates the dramatic change in platelet morphology that takes place upon activation and stabilizes thrombus formation. The Arp2/3 complex plays a vital role in these processes, providing the protrusive force for lamellipodia formation. The Arp2/3 complex is highly regulated by a number of actin-binding proteins including the haematopoietic-specific protein HS1 and its...
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