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Article

Platelets from mice lacking the aryl hydrocarbon receptor exhibit defective collagen-dependent signaling.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2014

Lindsey S, Jiang J, Woulfe D, Papoutsakis E T

Abstract excerpt

BACKGROUND: We previously identified aryl hydrocarbon receptor (AHR) as a novel regulator of megakaryocytic differentiation and polyploidization and reported that AHR-null mice have approximately 15% fewer platelets than do wild-type mice, yet they exhibit a dramatic, unexplained bleeding phenotype. OBJECTIVES: The current work tests our hypothesis that AHR-null platelets are functionally deficient, contributing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24410994
DOI: 10.1111/jth.12490
PMCID: PMC4008149

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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