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Article

Inhibition of the plasma SCUBE1, a novel platelet adhesive protein, protects mice against thrombosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2014

Wu Meng-Ying, Lin Yuh-Charn, Liao Wei-Ju, Tu Cheng-Fen, Chen Ming-Huei, Roffler Steve R, Yang Ruey-Bing

Abstract excerpt

OBJECTIVE: Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1), a secreted and surface-exposed glycoprotein on activated platelets, promotes platelet-platelet interaction and supports platelet-matrix adhesion. Its plasma level is a biomarker of platelet activation in acute thrombotic diseases. However, the exact roles of plasma SCUBE1 in vivo remain undefined. APPROACH AND RESULTS: We generated new mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24833801
DOI: 10.1161/ATVBAHA.114.303779

Genes

SCUBE1
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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